Amaso emagnethi asetyenziswa ikakhulu kuxilongo lwe-immune, ukuxilongwa kwemolekyuli, ukucocwa kweprotheyini, ukuhlela iiseli, kunye nezinye iinkalo.
I-Immunodiagnosis: Ubuhlalu be-Immunomagnetic buqulunqwe ngamasuntswana amagnetic kunye nezixhobo ezinamaqela asebenzayo asebenzayo. Iiproteni ligands (i-antigens okanye izilwa-buhlungu) zidityaniswe ngokudibeneyo kumaqela asebenzayo amaso emagnethi, emva koko i-immunoassay yenziwa kusetyenziswa iprotein ye-bead magnetic complexes.
Ukuxilongwa kwemolekyuli (i-nucleic acid extraction): Amaso emagnetic eNanoscale anamaqela angaphezulu anokuthi adsorb i-nucleic acid inokwahlulwa kwaye ibhengezwe yimagnethi, kwaye emva koko eluted ukufumana i-template nucleic acid.
Ukucocwa kweeprotheyini: I-agarose edityanisiweyo ngokudibeneyo idityaniswe neprotheyini edityanisiweyo ye-A/G kumphezulu wamaso kazibuthe, iprotein ethile ebophelelayo ye-ProteinA/G, kwaye ekugqibeleni iye yahluthwa ukufumana izilwa-buhlungu ezisulungekileyo.
Uxilongo lwamajoni omzimba kunye noxilongo lweMolekyuli:
Esinye sezona zicelo ziphambili zamaso ezibuthe kulele ekuxilongeni amajoni omzimba, apho ziye zaba zizixhobo eziyimfuneko ekubhaqweni kwezifo ezichanekileyo. Uphawu olulodwa lwamaso amagnetic luvela ekukwazini kwabo ukubamba kunye nokwahlula ii-antigens ezithile okanye ii-antibodies kwiisampuli zesigulane, ukwenza lula inkqubo yokuxilonga. Ngokudibanisa ngokudibeneyo iiprotheyini ze-protein, ezinjengee-antigens okanye ii-antibodies, kumaqela asebenzayo amaso amagnetic, abaphandi banokwenza i-immunoassays ngokufanelekileyo kunye nokuchaneka okuphuculweyo.Ukuxilongwa kwemolekyuli, enye inkalo ebangel’ umdla, ingenelwa kakhulu ekusebenziseni amaso emagnethi. Ngeendlela zokuxilonga iimolekyuli eziye zabalasela kwiminyaka yakutshanje, amaso azibuthe adlala indima ebalulekileyo ekwahluleni nasekukhupheni ii-nucleic acid, ezinje ngeDNA okanye iRNA, kwiisampulu zebhayoloji. Ezi ntsimbi zisebenza njengezixhaso eziqinileyo, ziququzelela ukubamba ngokufanelekileyo kunye nokuhlanjululwa kweeamolekyu ezijoliswe kuzo. Le ndlela ehamba phambili iye yenza ukuba izazinzulu zifezekise ukuxilongwa ngokuchanekileyo nangokuthembekileyo, okukhokelela kwiziphumo ezingcono zesigulane.
Ukucocwa kweProtheyini kunye noHlelo lweSeli:
Amaso amagnetic aphinda afumane ukusetyenziswa okubanzi ekucoceni iiprotheyini, inkqubo ebalulekileyo kuphuhliso lwamachiza kunye nophando lwe-biochemistry. Ngokudibanisa i-ligands ethile kwi-beads, abaphandi banokukhetha ukubopha kunye nokukhupha iiprotheni ezijoliswe kuzo kunye nokuhlanjululwa okuphezulu kunye nezivuno. Le ndlela yokucoca ikhawulezisa kakhulu inkqubo yophando ngokubanzi, ivumela izazinzulu ukuba zihlalutye kwaye zifunde iiprotheni ngendlela ecacileyo.Ukuhlela iiseli, icandelo elibalulekileyo kwizicelo ezahlukeneyo zonyango nophando, isengomnye ummandla ongenelwa kakhulu ngamaso kazibuthe. La maso, adityaniswe nee-biomarkers okanye amajoni omzimba, aququzelela ukubekwa wodwa kunye nokuhlelwa kweeseli ezahlukeneyo. Ngokusebenzisa imagnethi, izazinzulu ziyakwazi ukuhlela ngokufanelekileyo kwaye zahlule iiseli ngokusekelwe kumzimba kunye nokusebenza kwazo. Ukukhululeka kunye nokuchaneka kobu buchule kuye komeleza iinzame zophando ekuqondeni iinkqubo eziyinkimbinkimbi zeselula, ezifana nokuqhubekela phambili komhlaza kunye nokuphendula komzimba.
Ixesha lokuposa: Jun-25-2023